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FIGURE 3 3.4 Downstream effectors of the integrated stress response are upregulated following chronic exposure to DTG Given the upregulation of ATF4 and its target genes detected in the RNA-seq analysis and previous reports showing that some ART drugs lead to activation of the ISR in cultured rat neurons ( 1 /S phase (Figure 4A)
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Hortic Res 8 , 171 (2021)
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